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Conclusion In conclusion, we provide evidence that changes in the redox cellular state induce increases in peripheral NGF levels that orchestrate a neuroprotective response in the CNS, at least in the striatum, through the NGF/TrkA/Akt/Nrf2 pathway, including increased expression of genes involved in the uptake of the AAs L-cys and L-cys 2 and gclm , all of which are related to GSH synthesis and transport from the blood to the neuronal parenchyma