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[24] in 2021, following clinical evaluation of the association between myocardial fructose and sorbitol levels and indicators of cardiac dysfunction in diabetic patients, reported that myocardial sorbitol and fructose levels were significantly elevated in patients with T2DM

Heart, liver, kidney and brain tissues were rapidly removed and clamped frozen at liquid N 2 temperature and stored at80 C

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For instance, the breakdown of histidine in the gut produces imidazole propionate (IMP), which accumulates in the kidney