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Exhibiting 2- to 10-fold greater affinity for the androgen receptor (AR) relative to testosterone, DHT induces AR phosphorylation, nuclear translocation, and dimerization, thereby activating a transcriptional cascade that governs prostatic cellular homeostasis

Extensive evidences have highlighted the interaction between mitochondrial metabolic dysfunction, mtDNA damage, mitochondrial dynamics disorders, mitophagy dysregulation, and oxidative stress, while targeting oxidative stress represents a promising strategy for combating mitochondria diseases

In contrast to the lack of brain entry of dopamine in vivo [68], our results with the targeted dopamine-nanoformulation using the BBB model combined with midbrain organoids indicate that the nanoformulation may help dopamine to reach the brain tissue after BBB penetration

Another small study reported less stiffness in the arteries, a factor that contributes to high blood pressure