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Besides prescribing drugs that can slow progression, doctors can offer a range of medications to treat ALS-related symptoms, including modafinil (Provigil) for fatigue, mexiletine for muscle cramps, gabapentin (Horizant) for chronic pain, antidepressants for depression, and dexmedetomidine (Precedex) for sleep disorders

We further analysed the phagosome pathway based on animal model and research direction

Endocrine Modulation: DSIP is proposed to interact with hormones such as luteinizing hormone (LH) and growth hormone (GH), potentially contributing to sleep-related endocrine regulation

Delays in diagnosis and subsequent initiation in treatment of pernicious anaemia have been shown to increase the risk of irreversible neurological damage involving both the central and peripheral nervous system, resulting in permanent symptoms, such as peripheral neuropathy, cognitive impairment and damage to the spinal cord (known as subacute combined degeneration of the spinal cord)[9,16]