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24 This elevated incidence is partly due to the adverse effects caused by the administration of multikinase inhibitors, which include weight loss, nausea, and diarrhea

While, down-regulation of the transporter directly confers resistance against the drug, via decreasing the intracellular platinum concentration ( General Features of ATB 0,+ (SLC6A14) ATB 0,+ is a plasma membrane transporter belonging to the SLC6 family that includes amino acid transporters, neurotransmitter transporters, and osmolyte transporters (Pramod et al., 2013)