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This work was supported by the Maurice Phyllis Paykel Trust of New Zealand (Grant number: 9102 3727459) awarded to Drs S Reddy, K Sun and Professor A Davidson

Likewise, treatment with Lip-1 or with Lip-1 plus A2ARi increased stem-like phenotype (Figure 4K) of transferred OT-1 T cells, accompanied by an increase in the ratio of GSH to GSSG (Figure 4L) but a decrease in the levels of lipid ROS (Figure 4M) in comparison with control or A2ARi-treated CD8 + T cells

The elongated 2-oxo acid can then re-enter the elongation cycle or undergo transamination to form an elongated amino acid