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Researchers should also recognize that the combinations per-unit efficiency means that a well-designed combination protocol frequently achieves a larger research signal at a lower total compound cost than a single-compound protocol producing the same effect, which is part of why the combination dosing approach dominates the published GH-axis research literature

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Byproducts of this pathway, including fructose-3-phosphate and 3-deoxyglucosone, are strong glycosylating agents that promote AGE formation (54)

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