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Consequently, divalent iron converts lipids into reactive oxygen species (ROS), triggering ferroptosis

However, genetic inactivation of IIS in worms does not mitigate the negative effect of glucose on lifespan 13 (Fig

Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)