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This activates protein kinase A (PKA), which phosphorylates and stabilizes MITF (microphthalmia-associated transcription factor), driving transcriptional upregulation of tyrosinase, TRP-1, and TRP-2rate-limiting enzymes in the eumelanin biosynthesis pathway (Abdel-Malek et al., Pigment Cell Research, 2001)

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This interaction triggers a process called melanogenesis, where melanin is produced in higher amounts (1)

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In our case, due to uncharacteristic MRI and CT appearance, fine needle aspiration and drainage attempt was performed

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