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Brain 144 , 35053516 (2021)

48 116418 2021 Homo sapiens (P18031) brenda Hong, S.H

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The peptide directly activates IGF-1 receptors on target tissues including skeletal muscle, neurons, fibroblasts, and satellite cells, triggering powerful anabolic cascades through mTOR/PI3K-Akt pathway stimulation without prolonged systemic exposure