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Micelles not only significantly improve drug solubility, but also increase drug accumulation in tumor sites through enhanced permeability and retention (EPR), and they improve the effect of chemotherapy and can partially reverse tumor drug resistance (217)

Interestingly, ALS progression was not significantly affected by Nrf2 loss in multiple SOD1 mouse models (SOD1 G93A , SOD1 G85R or SOD1 H46R ) (Vargas et al