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9 Importantly, PCOS is a diagnosis of exclusion, meaning that other causes of ovarian dysfunction and hormone imbalance must be excluded to confirm a diagnosis

We therefore propose that tissue-associated oxidative stress may promote conversion of circulating TTR into dsNNTTR locally within the interstitial compartment, rather than exclusively during intracellular synthesis or processing

The accumulation factor (equation [7]) assumes that the drug follows a one-compartment model ( Figure 32 B), and the peak concentration prediction assumes that the absorption rate is much faster than the elimination rate

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