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ZH wrote the first draft of the manuscript

Meanwhile, NETs in the portal zone bind to fibronectin via 41 integrin, forming a three-dimensional scaffold that directs the extension of regenerating vessels (138).Metabolic reprogramming studies show that succinate released by portal zone NETs induces enhanced glycolysis in bile duct cells via the SUCNR1-GPR91 signaling axis, providing energy support for bile duct regeneration (139, 140)