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The transplantation of HLA (human leukocyte antigen)-matched sibling donor (MSD) cells into young class 1 or class 2 individuals on myeloablative conditioning (14 mg/kg busulfan + 200 mg/kg cyclophosphamide) and cyclosporin for graft-versus-host disease (GVDH) prophylaxis, gave excellent results (8290% disease-free survival), but this treatment was highly toxic in pediatric class 3 patients (only 55% survived) [78], [79]