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In this review, we summarize current evidence linking FOCM dysregulation to neurodegenerative diseases, emphasizing disease-specific mechanisms and the therapeutic potential of modulating folate metabolism, as evidenced by experimental and clinical studies

Confocal immunofluorescence microscopy All cells were fixed for 15 min with 4% cold paraformaldehyde, permeabilized with 0.2% Triton X-100, and stained for immunofluorescence microscopy