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Schnider, C

In vitro studies revealed that HOCl modifies and inactivates 1 -antiproteinase and 2 -macroglobulin, both of which are known to inhibit several proteolytic enzymes released from microbes and neutrophil granules in extracellular fluids [153, 319, 320]

Of note, NO avidly binds iron and is known to attack the active sites of a multitude of proteins, including heme and iron-sulfur clusters ([Fe-S]) [1]