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The formins FMNL1 and mDia1 regulate coiling phagocytosis of Borrelia burgdorferi by primary human macrophages

[DOI] [PubMed] [PMC] Homma ST, Wang X, Frere JJ, Gower AC, Zhou J, Lim JK, et al

Molecular Mass The Molecular weight of is 1419,5 Da as free peptide Specifical opt- rotation: [] 20 D = -155 0 (c = 1, water) IR spectrum (KBr): 3450, 3300, 2950, 2880, 1650, 1550, 1460, 1400, 1340, 1250, 1180, 1070 cm -1 1 H NMR spectrum (20% D 2 O/H 2 O: = 0.9 (14 H,m), 1.4 (10H,t, J, 1,7 Hz), 1,6 (8H,m), 2 (19H,m), 2,36 (7H,m), 2,7 (5H,m), 3 (2H,t, J 7,1 Hz), 3.9 (15H,m), 4,15 (2H,m), 4,25 (2H,m), 4,4 (2H,m), 4,6 (2H,m), 7,64 (1H,d J 8,6 Hz), 8 (1H,d, J 7,2Hz), 8,15 (1H,d, J 6,8Hz), 8,25 (2H,t, J 5,2 Hz), 8,33 (1H,d, J 7,2 Hz), 8,4 (2H,m), 8,45 (1H,d, J 5,1 Hz)

In the purine metabolism pathway, there were notable increases in xanthine and hypoxanthine concentrations, which rose by 26.6-fold and 18.3-fold, respectively, while ADP and AMP levels were downregulated, with slight decreases observed in adenosine and adenine (Figure 4C)