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It is essential for the catalytic activity of several classes of histone deacetylases (HDACs), as well as for the structural integrity and function of certain histone acetyltransferases, which together govern chromatin compaction and gene expression, and of DNA methyltransferases (DNMTs), which influence DNA methylation and processes such as lineage commitment and genomic imprinting 11

and Can reduce inflammation and skin damage

However, under conditions of overexpression, gene mutation, and Serine 129 phosphorylation, -syn aggregates abnormally and eventually forms neurotoxic oligomers, fibrils, and Lewy bodies [206, 207]

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