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Foot joints are especially vulnerable because they are cooler than other parts of the body and uric acid crystals are more likely to form in cooler environments

Administration of luteolin (80 mg/kg/day) resulted in a significant reduction in the activation of p-JNK, p38 MAPK, GFAP, Iba-1, and various inflammatory markers such as p-NF-B p65, tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), a decrease in pro-apoptotic proteins (including Bax, Caspase-3, Cox-2), a downregulation of BACE-1 and A1-42 concentrations, and an enhancement of synaptic markers (namely PSD-95, SNAP-25)

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