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Another study pointed out that pretreatment with 100 mg/kg NAC eliminated paclitaxel-induced allodynia in the CIPN mouse model, while in RAW264.7 cells, 50 mM NAC completely blocked the paclitaxel-induced release of high mobility group box 1 (HMGB1) and upregulation of CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) [63]

Yamaguchi Y, Kasukabe T, Kumakura S (2018) Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis

Globally, the World Anti-Doping Agency has also banned many of these injectables for professional athletes

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