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the latter are subjected to study in animal models for the elucidation of mechanisms leading to development and progression

These challenges include the short half-life and instability of the protein in vivo [106], the requirement of administering high volumes of endostatin to exert their anti-angiogenic effects, which in itself is associated with significant practical and cost implications [107], as well as technological challenges related to manufacturing a correctly folded and soluble protein to ensure adequate bioactivity within the tumour cells [108]

However, the bodys natural production of this molecule often declines as we age

High-Performance Liquid Chromatography confirms the compound makes up 99% or more of total content