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However, it has a short plasma half-life of 2030 min, necessitating continuous infusion over 812 h for 57 days a week, which significantly decreases patients compliance (Mobarra et al., 2016)

Moreover, it had been previously verified that DDP induced pyroptosis rather than apoptosis in normal tissues with high expression of GSDME, such as small intestine and lung tissues, leading to chemotherapy-mediated organ injury 9

Our results showed that the relative abundance of Corynebacterium was negatively correlated with (+/-)-tryptophan and myo-inositol and positively correlated with inosine, suggesting that Corynebacterium could alter the levels of related metabolites, thereby regulating amino acid and nucleotide metabolic pathways

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