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Of these, Glu4.2 also co-expressed Ramp3 across all species (see Extended Data Figs

Iron uptake and the labile iron pool (LIP) Extracellular Fe3+ typically binds to transferrin and enters cells via endocytosis through transferrin receptor 1 on the cell membrane

doi: 10.1016/j.chom.2020.12.006 50 MuncanVHeijmansJKrasinskiSDBllerNVWildenbergMEMeisnerSet al

Furthermore, elesclomol significantly reduced the spare respiratory capacity of mitochondria but left basal and ATP-linked respiration unaffected, suggesting that the copper may target TCA cycle components directly, without disrupting ETC activity or ATP generation