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Nemeth, Iron homeostasis in host defence and inflammation

In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury ( In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury (Zhao et al., 2025c)

Overall, these data indicate that the weight of glutamatergic synaptic drive in the NAc core is altered by the NAC treatment, such that D1-MSNs receive larger excitatory inputs, while these are overall reduced in D2-MSNs