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The results revealed that the compound exhibited favorable sustained-release characteristics in PBS buffer (pH 7.4) at 37 C (Figure 3A, the 3b series compounds demonstrated higher cumulative H 2 S release

log 2 FC = 20.46), a Ca 2+ regulator affecting acute kidney injury [39, 40], ERLINs, which regulate IP 3 receptors, DNAJs regulating degradation, and ARFs controlling G-protein coupled receptors (GPCRs)

Although iron overload is a major characteristic of ferroptosis, its potential regulatory mechanisms are still unknown

340 Furthermore, the increased production of inflammatory mediators like TNF- and the activation of stress kinases such as JNK, PKR, and IKK could promote the inhibitory serine phosphorylation of IRS-1, downregulate insulin signaling in the brain, and induce AD neurological dysfunction