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Do not double the dose, as this increases the overdose risk without improving effectiveness

Your body might recognize these degraded fragments as foreign proteins, leading to increased injection site reactions or antibody development that could theoretically reduce the effectiveness of future tirzepatide doses

Zhu Y, Wang H, Fang J, Dai W, Zhou J, Wang X, et al

Key distinctions matter because they guide evaluation: a globus sensation without difficulty swallowing or breathing is usually benign, whereas actual trouble swallowing (dysphagia), pain when swallowing (odynophagia), or any breathing difficulty should prompt faster medical assessment