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The SCALE phase 3a trials discussed in this paper were designed prior to the recent regulatory requirements for intercurrent events and hence patients discontinuing randomized injections or violating the protocol were withdrawn from the trials and only invited in for a landmark visit to assess the body weight

Ethics statement The studies involving humans were approved by Amsterdam UMC location, Vrije Universiteit Amsterdam, Department of Hematology/Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands

With more receptors, neurons attempt to restore the signals to normal

Short takeaways B12 injections reliably correct deficiency and often restore energy quickly, but they are not a proven weight-loss therapy for people with normal B12 levels