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A number of plants, such as Senecio salignus, Chenopodium ambrosioides L., and Cannabis sativa L., contain caryophyllene oxide, a natural bicyclic sesquiterpene that possesses significant anti-HCC activities by promoting ferritinophagy and ferroptosis (122)

Using structure-based analyses and cell models, including patient fibroblasts, of this variant, we found that the missense variant destabilized a critical loop, which disrupted the active site and caused a substantial loss of enzymatic function

Besides these two noble metal NPs, several other metal oxide NPs (iron oxide and silica) have also been used as therapeutic and contrast agents for PDs

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