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Copper-induced NLRP3 inflammasome-dependent pyroptosis and activating pro-inflammatory transcription factors in macrophages further amplify and strengthen the feedback loop to increase the level of inflammation represented by IL-1, suggesting that copper is related to the regulation of local immune function in the lungs (152)

The negative zeta potential of FA-CMC-GNA NPs is due to the presence of carboxylate groups from carboxymethyl chitosan (CMC) on the surface of the nanoparticles