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In the future, we will combine Western blot and immunofluorescence experiments to purposefully elucidate the molecular mechanisms of PI3K, p53, and other candidate pathways in the progression of RRM2 -mediated PTC, providing a more complete theoretical basis

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Such details, according to the letter, would aid organizations like APC in educating pharmacists, technicians, and other stakeholders about the reasons behind adding substances to Category 2 and the inherent risks perceived by the agency in compounding with them

Colonna and Holtzman, 2025)