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Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression

While it is generally agreed that pharmacological treatment beyond an acute response in mania is desirable, both for maintenance of the initial response and for prevention of new manic episodes, there are no data to support the benefits of divalproex sodium (Depakote ER) extended-release tablets in such longer-term treatment (i.e., beyond 3 weeks)

Consistent with this, increases in levels of p16 (CDKN2A) (1.23 fold) and p21 (CDKN1A) (1.48 fold), which are often augmented in senescent cells 48,49,50 , were also detected in chronically-irradiated cells, but do not appear in Fig