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Limitations of oral supplementation: Poor and unpredictable absorption of Vitamin B12 Patient non-compliance due to long duration of treatment High cost of therapy without assured results Limitations of parenteral supplementation: Painful and inconvenient, leading to patient non-compliance Time consuming & inconvenient clinic visits for the administration High cost of therapy Oral is not absorbed well

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It accelerates the healing of corneal epithelial defects and prevents neovascularization, which is crucial for preserving corneal clarity

some children showed sustained increases in growth velocity over 12-36 months of therapy, while others responded less robustly (somatropin GH is generally more potent)