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The 72-patient TBI cohort study reported memory and headache improvements during a course of oral treatment combined with standard therapy, not as a single peak effect

Beyond simple biomechanics, where each 1 kg of weight gain multiplies knee joint load by 34 kg, accelerating cartilage wear and activating pathogenic pathways like Wnt/ -catenin, the endocrine function of fat is paramount (14, 15)

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The possible sources are: (1) decreased expression and activity of cellular antioxidant systems (discussed above), or (2) increased production of ROS through major sources, such as mitochondria, that overcome the cellular antioxidant capacity, or (3) both