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Description

Glucarpidase for treating adults with delayed methotrexate elimination due to impaired renal function: an economic simulation analysis

Patten DA, McGuirk S, Anilkumar U, Antoun G, Gandhi K, Parmar G, et al

This physiological mechanism, which is useful for the post-translational modification of multiple proteins and for the regulation of signal and metabolic pathways, can turn harmful in case of oxidative stress, with the above-mentioned mitochondrial damage

Loss of GPX4 led to neurodegeneration and reduction of PV+ interneurons (Nahar et al., 2021), which are sensitive to oxidative stress (Wirth et al., 2010)