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Jiang, R

19 Although the mechanisms underlying endothelial dysfunction are multifactorial, a growing body of evidence suggests that increased ROS production contributes considerably to this phenomenon in several ways

A decrease in the lactase enzyme, which occurs after weaning, and damage to the lining of the digestive tract can be responsible for lactose intolerance (173)

wrote in the abstract of a paper published in 2024: The pathophysiology of ALS [Amyotrophic Lateral Sclerosis] involves many signs of a disruption in copper homeostasis, with both excess free levels and functional deficiency likely occurring simultaneously (Min et al., 2024)