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Initially, we find that expression of G2019S LRRK2 or WT ArfGAP1 alone markedly and equivalently reduce neurite length by 35-40% compared to WT LRRK2 or control (empty vector) neurons ( Fig

At the tumor site, PMIR effectively inhibits glutamine metabolism in tumor cells, leading to an elevation in intratumoral glutamine levels and improving immune cell functionality, ultimately reshaping the immunosuppressive TME and evoking robust immune responses [204]