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The main manifestations of the decline in HBV-specific CD8 + T cell function in CHB patients are antigen-specific loss and proliferation limitation resulting in low frequency, as well as high expression of inhibitory receptors such as programmed death-1 (PD-1), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), T cell immunoglobulin and mucin domain-3 (TIM-3) (Figure 2) [44]

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Schweizer L, Kenny HA, Krishnan R, Kelliher L, Bilecz AJ, Heide J, et al

Zabocka A, Janusz M, The two faces of reactive oxygen species, Postepy Hig Med Dosw