nrf2 glutathione peroxidase plays a critical role in mitigating lipid peroxidation and ferroptosis Frontiers | Nrf2 and Ferroptosis:

During osteoclastogenesis, RANKL-induced ROS induced PGC-1 via activation of CREB, and PGC-1 increased the production of reactive oxygen species and mitochondrial biogenesis, leading to the induction of osteoclastogenesis through a positive feedback mechanism [11, 12, 44, 45]

A comprehensive guide to assess gut mycobiome and its role in pathogenesis and treatment of inflammatory bowel disease

Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor gamma coactivator 1alpha

Mitochondrial bioenergetics is closely associated with lipid metabolism, and lipid accumulation and metabolic dysregulation in podocytes lead to mitochondrial dysfunction, which results in podocyte injury