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Following subcutaneous injection, the peptide rapidly enters systemic circulation with peak concentrations achieved in approximately three to six minutes

Thats because peptides degrade easily in the digestive tract and tend to be too large molecularly to permeate the skin or intestinal lining,5 often yielding a bioavailability as low as 1-2%.6 But there are some peptides that have a small enough molecular size that they easily transfer into the bloodstream as either an oral or a topical supplement