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Gonzlez-Zorn et al

Clonal evolution under therapy intersects with adaptive non-genetic mechanisms, providing a transition to adaptive resistance mechanisms discussed below

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In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients