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OASIS trials: establishing effective doses Phase 2 OASIS 1 findings: Tested multiple dose levels: 0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg weekly Duration: 26 weeks Primary endpoint: Weight loss at each dose Dose-response results: 0.3mg weekly: ~4% body weight loss 0.6mg weekly: ~6% body weight loss 1.2mg weekly: ~8% body weight loss 2.4mg weekly: ~10% body weight loss 4.5mg weekly: ~12% body weight loss Key insight: Clear dose-response relationship

Following administration of phenobarbital via drinking water to F344 rats for three weeks, increased liver weight was found to be a result of hepatocellular hypertrophy, hyperplasia, and enlargement of the hepatic blood space (Massey and Butler 1979)

Wissowa (1912) cites three passages from Horace, Carmina : I 1, 25 manet sub Iove frigido venator

Vegetarians, vegans, older adults, and those with absorption issues like Crohns disease or celiac disease are at risk of B-12 deficiency