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By incorporating modifications such as the substitution of Arginine for Glutamic Acid at the third position and extending the peptides N-terminus, IGF-1 LR3 exhibits an enhanced biological activity and a significantly prolonged half-life of approximately 20-30 hours in the human body

In hTYR, the hydroxylphenyl group of Arbutin_c, which originally coordinated with CuA, shifts and instead coordinates with CuB during the simulation (Fig