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In addition, HSV-1 has been reported to induce apoptosis in brainstems of mice infected with this virus, in which significant TUNEL-staining was observed at day 6 post-infection, although with low levels of detectable infectious virus, suggesting death of cells that were bystander to those infected with HSV-1 (Shaw et al., 2002)

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Power analyzes evaluated false discovery rate (FDR) of the identified DEGs in the above tissues and found the FDR values were less than 0.05, which support high credibility and exclude technical artifacts in these DEG detection (Supplementary Figs

However, research focusing on cannabis use in seniors is scarce, not to mention research specific to its impact on myelination