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When we compared the ratios of the GGMT for vaccine-matched viruses and the GGMT for mismatched viruses, the difference between mosaic E2E1-NPs and the E2E1-NP cocktail was statistically significant ( p = 0.026), suggesting that the mosaic nanoparticles were more likely to induce cross-reactive responses and cocktails of nanoparticles are more prone to induce autologous NAbs (Fig

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