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Your best bet is to follow the recommended dosage on the packaging, in conjunction with guidance from your doctor or a registered dietitian, Sheth says

Biotechnol 96 (2012) 14111420

Ergothioneine levels are typically low in the commonly consumed commercial button mushroom species prevalent in Western diets, such as Agaricus bisporus

Using isotope labelled arginine and fluorescent-tagged spermine, they found that the highly increased arginine upon AC engulfment (in vitro) does not contribute to de-novo polyamine synthesis, but rather that polyamine import from the environment is increased upon efferocytosis [80]