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In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]

Heterozygotes (1 per 500 people) typically exhibit a 30% increase in the duration of skeletal muscle blockade after a standard dose of succinylchloline, whereas homozygotes (1 per 2000 to 5000 people) can experience 2-3 hours of neuromuscular blockade (Thomsen et al, 2015