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It remains to be understood the exact mechanisms by which adipocyte-generated ceramides promote lipotoxicity

10.1016/j.scispo.2018.02.006 172 ZhouQ.ZhuX.-J.LiJ.-H

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In addition, delivering an antigen without the necessary co-stimulators causes T cell ignorance, anergy, or even T cell deletion (Hailemichael et al., 2013)