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The dose-response curve between 8 and 12 mg shows diminishing returns, meaning 10 mg captures most of the benefit while potentially reducing some of the dose-related side effects seen at 12 mg

You may also want to see a neurologist at a headache clinic with a sub-specialty in headache treatment

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Oxidative stress and Parkinson: Role of astrocytes In the brain, oxidative stress and other toxic insults can trigger the overexpression and activation of neuronal nitric oxide synthase that increases NO production and may cause apoptotic cell death by inducing the release of cytochrome c from mitochondrial impairment, loss of membrane potential, the opening of permeability transition pores, and the release of proapoptotic molecules [46,47]