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Large-scale randomized controlled trials Current clinical trials are predominantly constrained by insufficient sample sizes, single-center designs, and short intervention durations

445 Immunotherapeutic treatments have shown significant efficacy in TNBCs due to tumor immune infiltration, neoantigens caused by mutational burden and higher genomic instability, and high levels of immune markers such as PD-L1 and programmed cell death 1 (PD-1)

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