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Results BSO synergistically enhanced L-PAM-induced cytotoxicity in nine MM cell lines, in presence of BMSC and MM cytokines, and in seven primary MM cells We determined the cytotoxicity of clinically achievable levels of BSO (0400 M) and L-PAM (050 M) in nine human MM cell lines using the DIMSCAN cytotoxicity assay (Figure 1a)

doi: 10.1007/s10067-009-1347-0

Contributed reagents/materials/analysis tools: ES RHS RvZ DR PA KB

This hypothesized proteolytic knockdown of components of both the thioredoxin and glutaredoxin systems is consistent with a viral strategy to inhibit DNA synthesis, to increase the pool of ribonucleotides for RNA synthesis, thereby enhancing virion production